Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and -independent pathway.

In humans, paralytic poliomyelitis results from the invasion of the central nervous springer front end accessories system by circulating poliovirus (PV) via the blood-brain barrier (BBB).After the virus enters the central nervous system (CNS), it replicates in neurons, especially in motor neurons (MNs), inducing the cell death that causes paralytic

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SAliBASE: A Database of Simulated Protein Alignments

Simulated alignments are alternatives to manually constructed multiple sequence alignments for evaluating performance of multiple sequence alignment tools.The importance of simulated sequences is recognized because their true evolutionary history is known, which is very helpful for reconstructing accurate phylogenetic trees and alignments.However,

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